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The lack of available reliable detections assays and the dynamic, unpredictable nature of these substances prevent consistent, quality case reporting of Spice abuse in the literature. Detection and identification of the new potential synthetic cannabinoids 1-pentyl 2-iodobenzoyl indole and 1-pentyl 1-adamantoyl indole in seized bulk powders in Hungary. Although the plant material is most likely only an inert vessel for the active synthetic cannabinoids, the pharmacology and toxicology of the plant material used in these incense blends is also unknown. Seely1 Jeff Lapoint2 Jeffery H. Below is a summary of information available on the acute psychoactive and physical effects associated with synthetic cannabinoid use. Cannabinoids modulate prefrontal cortex neural functioning by decreasing the release of GABA and increasing extracellular glutamate and dopamine levels Ferraro et al.